San Francisco 49ers 2021 Fantasy Preview

San Francisco 49ers

2020 Record: 6-10

2021 Over/Under: o/u 10.5

2021 Divison Odds : +170

2021 Super Bowl Odds: +1350

As you prepare for the fantasy season, whether it be your home league, a big money squad or with us at Champions Round, we want you to be as prepared as possible heading into the season. And most of all we want to see you win! 

After a disappointing 2020 season that saw them lose just about every important player on their team at one time or another, the 49ers are back with big expectations in 2021. The coaching staff is in flux a bit as the 49ers must break in a new defensive coordinator after Robert Saleh bounced to the Big Apple. But let’s be honest, this is the Kyle Shanahan show. And so long as Shanahan has a healthy QB, his teams are going to win. 

The 49ers made a giant splash in the draft by trading up from 12 to 3 to nab Trey Lance, who should have a big role this season. Jimmy Garoppolo is the Week 1 starter and the organization publicly supports him. There’s good reason to. He’s been good when healthy. But he’s never healthy. With Lance, the 49ers have one of the best insurance policies in the NFL. And if Lance is the guy, which he will be at some point this year, Garappolo is a heck of a backup. 

If the 49ers are healthy, this should absolutely be a playoff team and is a potential Super Bowl contender.

Champions Round “JUICE” Projections

2021 Expected Record: 10-7

2021 Expected Points Per Game: 26.3

2021 Expected Points Allowed Per Game: 22.7


Jimmy Garoppolo - Rank: QB35

JUICE Projections: 173-274 Passing, 63% Completion, 1985 Passing Yds., 11 TD, 4 INT; 26 Rushing Yds

When healthy, Jimmy G has been a rock solid QB for the 49ers, leading them to a Super Bowl appearance in 2019. However, he’s often been injured. Moreover, Shanahan and GM John Lynch clearly believe that the former Patriot is not dynamic enough to lead the team as the NFL transitions into this era of mobile QBs. I believe Garoppolo is a low end QB2 in most leagues and will not have much fantasy value by midseason.

Trey Lance - Rank: QB28

JUICE Projections: 194-317 Passing, 61% Completion, 2231 Passing Yds., 14 TD, 6 INT; 440 Rushing Yds, 6 Rush TD

Lance is the perfect new age QB. While he doesn’t have a ton of playing experience having only played basically one year at the FCS level, he does have a gigantic arm, pocket awareness and is incredible mobile. He’s also very intelligent and everyone has raved about him in the organization. We’ll see how he fares when he takes over for Garoppolo, but his fantasy ceiling could be massive. His rushing floor will automatically make him a QB1 in most league formats once he takes over full time QB duties. I am trying to draft Lance in all formats.


Raheem Mostert - Rank: RB48

JUICE Projections: 131 carries, 590 Rushing Yds, 4 Rush TD; 13 receptions, 96 Receiving Yds, 1 Rec. TD

Trey Sermon - Rank: RB37

JUICE Projections: 136 carries, 642 Rushing Yds, 7 Rush TD; 19 receptions, 129 Receiving Yds, 1 Rec. TD

Both Mostert and Sermon should thrive in this offense, as most backs do in the Shanahan scheme. Sermon, the rookie out of Ohio State, should have a huge role, especially in the second half of the season. Mostert is always ridiculously productive, but is never healthy. I believe both of them should be drafted ahead of their current ADP’s. I am all in on the 49ers running game. 

Over the course of the season the stats may not look impressive on the whole, but remember that fantasy football is a weekly game, at least in your home leagues. And the 49ers running backs should thrive on a week to week basis. Picking the right RB in that given week is crucial if you’re drafting the SF backs.


Brandon Aiyuk - Rank: WR25

JUICE Projections: 66 receptions, 871 Receiving Yds, 7 Rec. TD

Aiyuk should thrive with Garoppolo under center. He’s the WR1 on the 49ers and had an outstanding rookie season. The question for Aiyuk is how he fares in fantasy when Lance takes over. Having a young, mobile QB usually isn’t a good thing for elite receivers. I’m high on Aiyuk in general, but my sense is he won’t produce up to his ADP in 2021.

Deebo Samuel - Rank: WR49

JUICE Projections: 54 receptions, 693 Receiving Yds, 4 Rec. TD

I have the same concerns about Samuel when it comes to having Lance at QB. That being said, it’s almost like people have forgot about how talent Samuel is. He could be a sneaky piece if he drops in drafts.


George Kittle - Rank: TE3

JUICE Projections: 81 receptions, 943 Receiving Yds, 7 Rec. TD

Kittle is the clear TE3 in fantasy with enormous upside if he’s healthy. But once again, he has the same Lance issue. I think TE3 is his ceiling. His floor is probably TE6-8. I am avoiding Kittle given his cost at this point.

TL;DR 2021 San Francisco 49ers

  • The Trey Lance hype for fantasy is real and it’s spectacular
  • Bet big on the 49ers RBs: Mostert and Sermon.
  • Aiyuk will the be the WR1, but may not have as much upside as the industry thinks
  • Kittle is clearly the TE3, but that’s his ceiling. The floor is much lower.

Thanks for reading and good luck in your drafts! Next Up: the Seattle Seahawks!